PDRN (salmon DNA)
Trendy as a "regenerator"; the support is mostly injectable, not topical.
What the evidence says
Evidence comes from injectable/medical use; topical use is unproven.
How to use it
If you want to try it, treat it as what it is today: another hydrating, soothing serum. It doesn't photosensitize or irritate. What makes no sense is paying premium prices for the "regenerating" promise — that part is unproven topically.
What it pairs with
Compatible with everything, like any hydrating serum.
Frequently asked questions
What is PDRN or "salmon DNA"?
Polydeoxyribonucleotide: DNA fragments extracted from salmon sperm. In medicine it's used as an injectable (wound healing, tissue regeneration), which is where its scientific aura comes from. Korean clinics' injectable "skin boosters" made it trendy, and topical cosmetics borrowed the name.
Do PDRN serums work?
As hydrators, yes; as "regenerators", unproven. PDRN's evidence is from injection — bypassing the barrier. Applied on top of skin, a large DNA molecule has a very hard time reaching where it would need to act. No solid clinical trial has shown it works topically.